Pathology Resident Wiki
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Synonyms[]

  • CD246

Antibodies[]

Technical Info[]

Staining Pattern[]

Expression in Normal Tissues[]

Expression in Neoplastic Entities[]

Benign[]
Tumor name % Positive Staining Number of Cases
Inflammatory myofibroblastic tumor (IMT) 60%[1] 73[1] -


Intermediate/Uncertain Malignant Potential[]
Tumor name % Positive Staining Number of Cases


Malignant[]
Tumor name % Positive Staining Number of Cases
Anaplastic large cell lymphoma (ALCL)

Expression in Non-Neoplastic Entities[]

Pertinent Negatives[]

This antigen is typically NOT expressed by the following entities:

Practical Uses / Panels[]

  • ALK-1 positivity in Anaplastic Large Cell Lymphoma (ALCL) has a favorable prognostic significance (80% 5 year survival vs 40% 5 year survival observed in ALK-1 negative ALCLs).

Common Pitfalls[]

Related Links/Other Resources[]

References[]

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