Pathology Resident Wiki



Technical Info[]

Staining Pattern[]

Endoplasmic reticulum, nuclear envelope, and inner mitochondrial membrane.

Expression in Normal Tissues[]

  • Lymphocytes in mantle zone and T cell areas of lymph nodes

Expression in Neoplastic Entities[]

Tumor name % Positive Staining Number of Cases
Solitary Fibrous Tumor (Hemangiopericytoma) 100%[1] 16/16[1]
Cellular Blue Nevus[2]

Intermediate/Uncertain Malignant Potential[]
Tumor name % Positive Staining Number of Cases

Tumor name % Positive Staining Number of Cases
Synovial Sarcoma (including monophasic [MFSS] and poorly differentiated[PDSS])[3] MFSS 91%, PDSS 92%[3] MFSS 43/47, PDSS 12/13[3]
Follicular Lymphoma (Grade I, Grade II, Grade III) 97%, 83%, 74%[4] 107/110, 119/143, 71/96[4]
Clear cell sarcoma 94%[5] 30/32[5]

Expression in Non-Neoplastic Entities[]

Pertinent Negatives[]

This antigen is typically NOT expressed by the following entities:

Practical Uses / Panels[]

  • Follicular Lymphoma (positive germinal centers) vs. follicular/reactive hyperplasia (negative germinal centers)

Common Pitfalls[]

BCL-2 expression decreases with increasing grade in Follicular Lymphoma.

Laboratory Investigation (2004) 84, 235–244, advance online publication, 19 January 2004; doi:10.1038/labinvest.3700051

Related Links/Other Resources[]