Pathology Resident Wiki
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Synonyms[]

Antibodies[]

Technical Info[]

Staining Pattern[]

  • membranous

Expression in Normal Tissues[]

  • epithelial cells - exception of adrenocortical cells and Granulosa cells-
  • melanocytes -adhering to squamous epithelial cells-
  • Hematopoietic erythroid precursors

Weak

  • Liver cell epithelial
  • Mesenchymal cells- maybe and weak-
  • Testicular germinative cells

https://www.nordiqc.org/epitope.php?id=43


Expression in Neoplastic Entities[]

Expression in Neoplastic Entities[]

Benign[]
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments


Intermediate/Uncertain Malignant Potential[]
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments


Malignant[]
Tumor name % Positive Staining (Sensitivity) Number of Cases Specificity Comments
Ductal breast carcinoma
Melanoma 50%

Expression in Non-Neoplastic Entities[]

Pertinent Negatives[]

This antigen is typically NOT expressed by the following entities:

  • Lobular breast carcinoma

Practical Uses / Panels[]

Common Pitfalls[]

Related Links/Other Resources[]

References[]

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